9:10-dihydro-9:10-ethanoanthracen-9-alkanamides



Patented July 15, 1969 3,455,928 9:10-DIHYDRO-9:IO-ETHANOANTHRACEN- 9-ALKANAMIDES Paul Schmidt, Therwil, Max Wilhelm, Allschwil, and Kurt Eichenberger, Therwil, Switzerland, assignors to Ciba Corporation, New York, N.Y., a corporation of Delaware No Drawing. Continuation-impart of application Ser. No. 541,979, Apr. 12, 1966, which is a continuation-in-part of application Ser. No. 512,201, Dec. 7, 1965. This application Sept. 26, 1967, Ser. No. 670,769

Claims priority, application Switzerland, Nov. 29, 1960, 13,359/ 60; Oct. 10, 1961, 11,710/61; Nov. 1, 1963, 13,434/63; Dec. 23, 1964, 16,637/64; Nov. 24, 1965, 16,177/65; Dec. 10, 1965, 17,086/65 Int. Cl. C07d 51/72; C07c 103/86; A61k 27/00 US. Cl. 260-268 v 11 Claims ABSTRACT OF DISCLOSURE 9 R CO X 9:10- dihydro 9:10 ethano- (1:2)- anthracenes, wherein X is a direct bond or a lower alkylene radical and R is a substituted or unsubstituted amino group, are valuable intermediates for the preparation of 9 R alk 9:10 dihydro 9:10 ethano (1:2) anthracenes, wherein alk is a lower alkylene radical and R has the meaning given above, as well as of their quaternary ammonium compounds and salts, which compounds, especially the amines and the therapeutically acceptable salts thereof, can be used as tranquilizers.

CROSS-REFERENCES This is a continuation-in-part application of our copending application Ser. No. 541,979, filed Apr. 12, 1966, now US. Patent 3,399,201, which is a continuation-inpart of our application Ser. No. 404,904, filed Oct. 19, 1964, and now abandoned, which in turn is a continuation-in-part of our application Ser. No. 151,198, filed Nov. 9, 1961, and now abandoned, and of our' application Ser. No. 512, 201, filed Dec. 7, 1965, and now abandoned.

SUMMARY OF THE INVENTION The present invention concerns and has for itsobject the provision of new 9-R-CO-X-9z10 dihydro 9:10- ethano (1:2) anthracenes, wherein X is a direct bond or a lower alkylene radical and R is a substituted or unsubstituted amino group, which are valuable intermediates for the preparation of 9-R-alk-9:10-dihydro-9:10- ethano-(1:2)-anthracenes, wherein alk is a lower alkylene radical and R has the meaning given above, as well as of their quaternary ammonium compounds and salts, which compounds, especially the amines and the therapeutically acceptable salts thereof, can be used as tranfinal compounds by reduction with lithium-aluminium hydride or a similar reducing agent for amides.

DESCRIPTION OF THE PREFERRED EMBODIMENTS In the 9-R-alk-9:10-dihydro-9:10-ethano-(1:2)-anthracenes containing the nucleus of the formula substituted. Particularly suitable substituents are lower hydrocarbon residues which may be interrupted by heteroatoms such as oxygen, sulphur or nitrogen, and/or may be substituted by free hydroxyl, amino or mercapto groups or by halogen atoms such as fluorine, chlorine, bromine or iodine. As lower hydrocarbon residues there may be mentioned above all: Lower alkyl or alkenyl groups such as methyl, ethyl, propyl, or isopropyl;

straight or branched butyl, pentyl, hexyl, or heptyl radicals bound in any desired position; allyl or methallyl radicals; unsubstituted or alkyl-substituted cycloalkyl or cyclo-alkenyl groups such as cyclopentyl, cyclohexyl, cycloheptyl, cyclopentenyl, cyclohexenyl groups; unsubstituted or alkyl-substituted cycloalkyl-alkyl or cycloalkenylalkyl groups such as cyclopentylor cyclohexenyl-methyl, -ethyl or -propyl groups; aralkyl or aralkenyl such as phenyl-methyl, -ethyl, vinyl or propyl groups; or aryl, more especially phenyl radicals; or alkylene or alkenylene groups such, for example as butylene-(1:4), pentylene- (1:5), 1:5 dimethylpentylene (1:5), hexylene (1:6) and hexylene-(l :5). Residues of this kind interrupted by hetero atoms are, for example, alkoxyalkyl or oxa-cycloalkyl-alkyl groups such as methoxyethyl, ethoxyethyl, propoxyethy-l, butoxyethyl, methoxypropyl, methoxyethoxyethyl, tetrahydrofurylmethyl, methylmercaptoethyl, oxa-, azaor thia-alkylene or -alkenylene residues such as 3- aza-, oxaor thia-pentylene-(1:5), 3-aza-hexylene-(1:6), 1:5 -dimethyl 3 aza pentylene (1:5), 3 methyl 3 aza pentylene (1:5), or 3 hydroxyethyl 3 aza pentylene (1:5). The amino group is above all a monoor di-lowe-r alkyl-amino group such as the methylamino, ethylamino, n-butylamino, dimethylamino, diethylamino, dipropylamino, N methyl N ethylamino group, or an N lower alkyl N cycloalky-lamino group such as the N methyl N cyclopentyl or -cyclohexyl group; or a pyrrolidino, piperidino, morpholino or thia morpholino group such as the pyrrolidino, piperidino, morpholino, piperazino, N methyl-, N ethylor N [3 hydroxyethyl-piperazino group.

The fourth substituent on a quaternary ammonium group is above all a lower alkyl or alkenyl group such as a methyl, ethyl, allyl, propyl or benzyl group or a phenoxy lower alkyl such as the phenoxyethyl group.

The alkylene residue which connects the aforementioned amino group with the anthracene nucleus is above all a lower unbranched or branched alkylene group which preferably contains 1 to 4 carbon atoms such, for example as a methylene, ethylene-(1:2), propylene-(1:2), propylene (1:3), butylene (1:2), butylene 1:3), butylene (2:3) or butylene (124) residue.

The new compounds can be further substituted, for example, in positions 1 to 8 of the anthracene ring or on other aromatic rings by lower alkyl, alkoxy, alkenyloxy or alkylmercapto groups, by halogen atoms such as fluorine, chlorine, bromine or iodine or by the pseudohalogen trifluoromethyl, by alkylsulphonyl, alkanoyl, nitro or amino groups, and in this connection there may be mentioned as alkyl groups, for example, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, or tertiary butyl; as alkoxy or a'lkenyloxy groups the methoxy, ethoxy, allyloxy or methylenedioxy group; as alkylmercapto the methylmercapto or ethylmercapto group; and as alkanoyl groups above all the acetyl, propionyl or butyryl residue. In position 10 the new compounds may contain above all an aliphatic hydrocarbon residue such as one of the abovementioned lower alkyl or a'lkenyl groups, or a halogen atom.

The new compounds have valuable pharmacological properties: inter alia they can be used as tranquilizers in medicine. They are also suitable as additives to animal fodder, since they bring about a better intake.

mula

andtheifsalts; in 'Which A represents a secondary or' tertiary amino group, more more especially one of the last-mentioned amino groups, especially a dimethylaminoor methylamino group. Of primary importance are 9- methylaminomethyl, 9-n-butylamino-methyl-, 9-dimethylaminomethylor 9-diethylamino-methyl-9:IO-dihydro- 9: 10-eth ano- (1 :2 -anthracene, 9- y-dimethylamino-propyl- 9: l0-dihydro-9: IO-ethano-(l :2) -'anthracene, 9-7-methylamino propyl-9:l0 dihydro-9:l0-ethano-(l:2)-anthracene and '9 ['y (N-hydroxyethyl-piperazino)-propyl]- 9:10-dihydro-9:10-ethano-( 1,2)-anthracene and their salts.

The new compounds are prepared by as such known methods.

Thus, for example, a residue convertible into an aminoalkyl or ammonium-alkyl group, present in position 9 of a 9:10-dihydro-9:10-alkano-(1:2)-anthracene may be so converted. A residue convertible into an aminoalkyl or ammoniumalkyl group is for example one which is convertible into an aminoalkyl group by reduction, for example carbamyl, or carbamylalkyl groups which can be reduced in conventional manner, advantageously with lithium-aluminum hydride or a similar reducing agent for amides, to form the corresponding aminoalkyl groups.

Similarly, nitroalkyl, nitroalkenyl, cyano or cyanoalkyl groups can be reduced to the corresponding aminoalkyl groups, the reduction of said groupings being carried out with the use of a conventional agent such, for example as activated hydrogen, more especially catalytically activated hydrogen. Catalysts particularly suitable for this purpose are Rupe or Raney nickel, or platinum or palladium catalysts.

'Further groups that can be reduced to am'inoalkyl' groupsare iminoalkyl residues 'or the corresponding" amino-hydroxy-alkyl residues which can be converted into the aminoalkyl residues with the use of a conven-' tional reducing agent, primarily a-metal hydride,---for example a di-light metal'hydride, such as alkali metal boro-' hydride, o'r catalyticall'y" activated hydrogen, for which purpose platinum oxide an'dRaney nickel are especially suitable catalysts. A's iminoalkyl residues there are suitable, apart frOmthe usual 'Schiffsbases, also hydroxy-- imino-alkyl groups.

"According :to another process the 9:1O-Eth2mO-(1i-2) residue introduced in conventional manner into 'a 9- aminoal'kyl-anthracene, or into a 'quaternary' ammonium derivative" or'a saltfthereof, advantageously with the use of ethylene, :by tlie Die'ls Aldermethod; depending on the reactivityofthe anthracene'c'ompound thisreaction may have to :be carried out at an elevated temperature and/orunder su-peratmospheric pressure and/or in the presence of acatalyst ln aresulting primary,ij secon dary or tertiary amino group furthen nitrogen v substituents may be introduced in known manner for example by treatment with a re- 4 "iththe" tfsebf an appropriate carbonyl "compound or by acylation with carboxylic acids or their functional derivatives and reduction of the obtained N-acyl compounds.

Furthermore, substituents may be introduced into the benzene nuclei, such as nitro groups, which may be effected by nitration. substituents present in the molecule can be converted in the conventional manner, for example nitro groups on the aromatic'sresidues may be reduced to amino groups.

The invention further includes any variant of the presentprocess in which an intermediate obtained at any stageof the process 'is used as starting material and/or the remaining. step or steps 'is/are carried out; or the process is discontinuedat any stagethereof; or in which a starting material is formed in the course of'the reaction,.. or-used in the form of a' quaternary ammonium compound or a salt thereof.'Thus, for example, the starting material may be a 9-oxoalkyl-9:10-dihydro-9:10-t ethano-(1:2)-anthracene, for example a 9-formyl or 9- formylalkyl compound, which is treated under suitable reducing conditions, for example those mentioned above for reducing iminoalkyl groups, with ammonia or with a primary or secondary amine, which procedure yields as intermediate one of the aforementioned iminohydroxy or aminohydroxy compounds.

The aforementioned reactions are carried out in the usual manner in the presence or absence of diluents, CD11. densing agents and/or catalysts, at room temperature or a lower or higher temperature, if desired under superatmospheric pressure.

The starting materials are known or can be prepared by known methods. Any new starting materials used are likewise included in the invention.

Depending on the reaction conditions and starting material used the new compounds are obtained in the free form or in the form of salts thereof. The salts. of the new compounds can be converted in. known manner into the free compounds, for example acid addition salts by reaction with a basic agent. On the other hand, a resulting free base may form salts with inorganic or organic acids. Acid addition salts are preferably manufactured with therapeutically useful acids, for example a hydrohalic acid such as hydrochloric or hydrobromic acid,-perchloric, nitric or thiocyanic acid, a sulphuric or phosphoric acid,

or an organicacid such as formic, acetic, propionic, glycollic, lactic, pyruvic, oxalic, malonic, succinic, maleic, fumaric, malic, tartaric, citric, ascorbic, hydroxymaleic, dihydroxymaleic, benzoic, phenylacetic, 4-amino-benzoic, 4-hydroxybenzoic, anthranilic, cinnamic, mandelic, salicylic, ,4- aminosalicylic, 2-phenoxybenzoic, 2-acetoxybenzoic, methanesulphonic, ethanesulphonic,- hydroxyethanesulphonic, benzenesulphonic, para-toluene-sulphonic, -naphthalenesulphonic. or sulphanilic acid;- methionine,

tryptophan, lysine or arginine.;-The salts may be mono: salts orpolysalts,

Quaternary .arnmonium salts: may also be converted into the ammoniumhydroxides, for example by treatment of an .ammoniumhalide with freshly precipitated silver oxide,.or bytreating anammonium sulphate with barium hydroxide solution, or with the use of a basic ion-ex changer, and from the resulting ammonium hydroxide other an monium salts can be prepared by reaction with an acid, for exampleone. of those mentioned above. If

desired,-.;this exchange may also be carried out directly with the use of a'suitable ion-exchanger. v v

The new compounds are intended to be used as medicaments in the -form of. pharmaceutical preparations con- 7 tainingl them in conjunction with a pharmaceutical oror with a corresponding alcohol, or by reductive alkylgarlic-or inorganiq fsolid ,or liquid excipient suitablefor. enteral (for example oral -,or parenteral administration. Suitablefexcipient's are substances that do not react with the newvcompouhds such forexam Ie, as water, gelatine,

.lactos e,'.'starch, magnesium stearate, talc, vegetable oils,

benzyl alcoholsfgu rns, polyalkylene glycols, cholesterol or other known medicinal excipients. The pharmaceutical preparations may be, for example, tablets, dragees or capsules, or in liquid form solutions, suspensions or emulsions. They may be sterilised'and/or may contain assistantssuch as preserving, stabilising, wetting, or emulsifying agents, salts for regulating the osmotic pressure or buffers. The dosage of the new compounds may vary according to the particular compound and the particular needs of the patient. Usually, it is in the range of 25 500 mg. daily, for example between 75 and 300 mg.; the dose may be divided and thus administered twice or three times a day. They may also contain other therapeutically valuable substances.

The new compounds may also be used in veterinary medicine, for example in one of the forms mentioned above, or in the raising and feeding of animals in the form of fodders or as additives to animal fodder, for example in admixture with the conventional extenders and diluents and feeding stuffs respectively.

The following examples illustratethe invention.

EXAMPLE 1" A solution of 9.0 grams of 9:10-dihydro-9:IO-ethano- (l:2)-anthracene-(9)-carboxylic acid diethylamide in 50 cc. of tetrahydrofuran is stirred dropwise at room temperature into a suspension of 2.5 grams of lithiumaluminium hydride in 100 cc. of tetrahydrofuran. The mixture is heated for 3 hours at the boil and then cooled in ice. The organo-metal complexes and the excess of lithium-aluminium hydride are decomposed by carefully dropping in 2.5 cc. of water, 2.5 cc. of sodium hydroxide solution of strength and 7.5 cc. of water. The granular precipitate formed is filtered off and the solvent is evaporated, to yield 9-diethylamino-methyl-9:10-dihydro'-9:10-ethano-(1 :2)-anthracene of the formula which melts at 112 to 115 C. after having been re crystallised from ethanol. Its hydrochloride melts at 243 to 245 C.

The 9:10-dihydro-9z10-ethano (1:2-anthracene (9) carboxylic acid diethylamide used as starting material is prepared in the following manner:

A mixture of 10.0 grams of 9:10-dihydro-9z10-ethano- (1:2)-anthracene-(9)-carboxylic acid and 100 cc. of thionyl chloride is refluxed for 6 hours; the thionyl chloride is then evaporated to leave an oil which crystallises when left to itself for some time. Recrystallisation from petroleum ether yields the 9: 10-dihydro-9: 10-ethano-(1':2)- anthracene-(9)-carboxylic acid chloride of the formula co-c1 in crystals melting at 72 to 75 C. r

10.0 grams of diethylamine in cc. of benzene are vigorously stirreddropwise at room temperature into 5 grams of the acid chloride in 50cc. of benzene. The mixture is stirred for 2 hourstat 40 C. and then extracted with water. On evaporation of the benzene an oil remains which crystallises slowly. Recrystallisation from aqueous methanol yields the 9:10-dihydro-9z10- ethano 1 :2 -anthracene- (9 -carboxylic acid diethylamide of the formula in crystals melting at 108 to 109 C.

EXAMPLE 2 mula CH2-NH-CH2-CH2- Q act which melts at 253 to 255 C. after having been recrystallised from ethanol+ether.

The 9:10 dihydro 9:10 ethano-(1:)-anthracene- (9)-aldehyde used as starting material is prepared as follows:

A solution of 50 grams of anthracene-(9)-aldehyde in 200 cc. of dimethylformamide is heated in an autoclave with ethylene to 170 C.; the whole is cooled after 24 hours, and the solvent is evaporated in a water-jet vacuum. The residue is dissolved in .a small amount of chloroform. On addition of ethanol the 9:10-dihydro-9:10- ethano-(l:2)-anthracene-(9)-aldehyde of the formula CHO crystallises in the form of prisms melting at 106 to 107 C.

EXAMPLE 3 A solution of 10.0 grams of 9: 10-dihydro-9: 10-ethano- (l:2)-anthracene-(9)-aldehyde and 5.0 grams of n-butyl amine in 150 cc. of benzene is boiled for 2 hours with the use of water separator and then evaporated to dryness. The residue is dissolved in cc. of ethanol, treated with 2.0 grams of Raney nickel and hydrogenated at room temperature under atmospheric pressure. When hydrogen is no longer being consumed,'the catalyst is filtered off and the solvent evaporated, to yield 9-(11- butyl amino methyl) -.9: ;10 dihydro-9:10-ethano- (1:2)-anthracene of the formula which melts at 76 to 78 C. after having been recrystallised from ethanol.

EXAMPLE 4 A solution of 10 grams of 9:10-dihydro-9:l0-ethano- (l:2)-anthracene-(9)-aldehyde and 10 grams of monomethylamine in 100 cc. of ethanol is heated at 80 C. for 4 hours in an autoclave. The reaction mixture is then evaporated to dryness under reduced pressure to leave a crystalline residue which is dissolved in 150 cc. of ethanol and, after the addition of 2 grams of Raney nickel, hydrogenated at 40 C. under atmospheric pressure. When the absorption of hydrogen has subsided, the catalyst is filtered off and the filtrate evaporated under reduced pressure. An oil remains which is covered with 100 cc. of 2 N-hydrochloric acid. The 9-methylamino-methyl- 9:10 dihydro-9:IO-ethano-(l:2)-anthracene hydrochloride of the formula cit -MIME crystallizes immediately; after crystallization from methanol it melts at 320-322 C.

EXAMPLE 5 A mixture of 10 grams of 9-methylamino-methyl-9:10- dihydro-9:10-ethano-(1:2)-anthracene, 4 cc. of aqueous formaldehyde solution of 30% strength and 5 cc. of formic acid is heated at 90 C. for hours. After cooling, the reaction mixture is rendered alkaline by the addition of 2 N-sodium hydroxide solution. The oil which has separated is extracted with methylene chloride and the extract evaporated. There remains 9-dimethylaminomethyl-9: -dihydro-9: 10-ethano-( 1 :2) -anthracene of the formula chloride.

EXAMPLE 6 A solution of 17.8 grams of N-acety1-9-methyl-aminomethyl 9:10-dihydro-9:lfl-ethano-(lzZ) anthracene in 50 cc. of tetrahydrofuran is added dropwise, with stirring, to 4 grams of lithium-aluminium hydride in 100 cc. of tetrahydrofuran. The mixture is then stirred for 2 hours at 50 C. 4 cc. of water, 4 cc. of sodium hydroxide solution of strength and 12 cc. of water are then added to the reaction mixture, the precipitate formed is filtered with suction and the filtrate evaporated to dryness under reduced pressure to yield 9-(methyl-ethylamino-methyl)-9:10-dihydro-9z10 ethano (1:2) anthracene of the formula.

which melts at 77-79 C. after crystallization from methanol; its hydrochloride melts at 235-236 C.

The N-acetyl-9-methylaminomethyl-9:10 dihydro- 9:lO-ethanol-(l:2)-anthracene used as starting material may be prepared in the conventional manner by acetylating 9-methylamino-9:10-dihydro-9:10-ethano (1:2) anthracene with acetyl chloride in pyridine. The compound melts at 128 C. after recrystallization from ethanol.

8 EXAMPLE 7 10 grams of 9-cyano-9:10-dihydro-9:10-ethano-(1:2)- anthracene are dissolved in 200 cc. of ethanol. The solution is saturated with ammonia and after the addition of 2 grams of Raney nickel hydrogenated at C. under 70 atmospheres gauge pressure. When the absorption of hydrogen has subsided, the catalyst is filtered off and the filtrate evaporated to dryness under reduced pressure. The residue is treated with 2 N-hydrochloric acid, the hydrochloride of 9 aminomethyl-9zl0-dihydro 9:10- ethano-(1:2)-anthracene of the formula precipitating in the form of crystals melting at 313-315 C.

EXAMPLE 8 Ethylene is introduced into a solution of 10 grams of 9-dimethylamino-methyl-anthracene in 300 cc. of benzene in an autoclave up to 45 atmospheres gauge pressure, and the mixture is then heated for 12 hours at 170 C.

After the reaction has ceased, the benzene solution is extracted with 2 N-hydrochloric acid, the acidic extract rendered alkaline by the addition of sodium hydroxide solution, and the precipitated base extracted with methylene chloride. After drying and evaporation of the solvent there remains 9-dimethyl-amino-methyl-9:IO-dihydro- 9:10-ethano-(1:2)-anthracene of the formula which is converted into its hydrochloride of M.P. 234 C. by the addition of ethanolic hydrochloric acid and diethyl ether.

The 9-dimethylamino-methyl-anthracene used as starting material may be prepared as follows:

20 grams of 9-chloromethy1-anthracene are heated with 10 grams of dimethylamine in cc. of ethanol for 5 hours in an autoclave at 100 C. The reaction mixture is then evaporated to dryness under reduced pressure, the residue dissolved in ether and the solution extracted with 2 N-sodium hydroxide solution. After drying and evaporation of the ethereal solution there is obtained 9-dimethylamino-methyl-anthracene which after crystallization from ethanol melts at 65-66 C.

EXAMPLE 9 12 grams of ,8-[9z10-dihydro-9:10=ethano-(1:2)-9-anthryl]-propionic acid dimethylamide in 50 cc. of tetrahydrofuran are added dropwise with stirring at room temperature to a suspension of 3.5 grams of lithium-aluminium-hydride in 100 cc. of dry tetrahydrofuran; the mixture is then boiled under reflux for 2 hours. 4 cc. of water and 10 cc. of sodium hydroxide solution of 15 strength are then added dropwise while cooling with ice, and the precipitate which settles out is filtered. The filtrate is evaporated to dryness under reduced pressure, the oily residue dissolved in ether and the ether solution extracted with 2 N-hydrocholoric acid. The acidic solution is rendered alkaline by the addition of 10 N- sodium hydroxide solution and the precipitated base extracted with ether. After drying and evaporation of the v.9. extract there is obtained 9 y -dimethylarnino-propyl-9:I0- dihydro-9:l0-ethano-(l:2)-anthracene of the formula which melts at 88-90 C. after sublimation; its hydrochloride melts at 205-206 C.-

The [9:l0-dihydro-9:10-ethano-(1:2)-9-anthryl]- propionic acid dimethylamide used as starting material may be prepared as follows:

A solution of grams of fl-(9-anthryl)-propionic acid [prepared as described by F. H. C. Stewart, Australian Journal of Chem. 13, 483 (1960)] in 200 cc. of dimethylformamide is saturated with ethylene and the mixture heated in an autoclave for 24 hours at 170 C. After cooling, 500 cc. of water are added the precipitate formed filtered oil. The precipitate is recrystallized from ethanol to yield ,9 [9:10 dihydro 9:10 ethano (1:2) 9- anthryH-propionic acid of the formula V CH CH COOH in the form of crystals melting at 218-219 C. I

10 grams of the above acid areboiled with '500 cc. of thionyl chloride for 4 hours and. the mixture evaporated to dryness under reduced pressure to yield a crystalline residue which is dissolved in 50 cc. of benzene. To this solution there is added dropwise at room temperature, with stirring, a solution of 5 grams of dimethylarnine in 50 cc. of benzene. After 2 hours 100 cc. of water are added, the benzene layer separated, dried over sodium sulphate and evaporated. There: remains crystalline B- [9210 dihydro- 9:10 ethano (1:2) 9 anthry1]- propionic acid dimethylamide which can be used without further purification.

EXAMPLE 10,

A solution of 14.0 grams of 2-chloro-anthracene-(9)- aldehyde in 200 cc. of dimethyl-formamide is saturated with ethylene and then heated in an autoclave-for 24 hours at 170 C. The dimethylformamide is then distilled off in vacuo. A viscous oil remains behind which is dissolved in 100 cc. of ethanol; after the additionof 10 grams of monomethylam'ine, the reaction mixture -is heated in a bomb tube for 4 hours at 90 C. The-solution is evaporated to dryness, the residue dissolved in 200-cc. of ethanol and, after the addition of 2 grams of 'Raney nickel, hydrogenated under 5 atmospheres gauge pressure. After filtering oil the catalyst, 'the reaction mixture is evaporated to dryness underlreducedpi'essure.'The residue is boiled with 100 cc.- of 2 N-hydro'chloric acid and the hydrochloric acid solution is separated-bit. On cooling, an oil separates which crystallizes after'being allowed to stand for some time. There is obtained 2- chloro 9 methylamino methyl 9:10 5 dihydro} 9510- ethano (1:2) anthracene hydrochloride of the formula' i in the form of White crystals which melt at 223-226? C. after crystallization from water.

The 2 chloro anthracene (9) aldehyde used as starting materi'almay be prepared as follows:

A. mixture of 42 grams of 2-chloro-anthracene, 54 grams of N-methyl-formamide', 60 grams of phosphorus oxychloride and cc. of dichloro-benzene is heated for 2 hours at 90-95 C. with stirring. A solution of 280 grams ofcrystalline sodium acetate in 500' cc. of water is thenadded. A precipitate settles out which is filtered oil and boiled with ethanol. The hot ethanol solution is filtered. On cooling the filtrate, 2-chloro-anthracene-(9)- aldehyde separates in the form of yellow needles which melt at 148-150 C. after recrystallization from glacial acetic acid.

EXAMPLE 11 A solution of 5.0 grams of dimethylarnine in cc. of benzene is added dropwise and with stirring to 4.0 grams of 1:5 dichloro 9:10 dihydro 9:10 ethano (1:2)- anthracene-9-carboxylic acid chloride in 50 cc. of benzene at room temperature. After 2 hours, 100 cc. of Water are added and the benzene layer is evaporated to dryness under reduced pressure. The residue is dissolved in 50 cc. of absolute tetrahydrofuran and the resulting solution added dropwise and with stirring to a mixture of 2.0 grams of lithium aluminium hydride and 50 cc. of tetrahydrofuran. The mixture is heated to the boil for 2 hours and then decomposed by the addition of Water and sodium hydroxide solution of 15% strength. After filtering off the precipitate which has settled'out and evaporating the filtrate, an oil remains which is dissolved in 10 cc. of ethanol. The solution is treated with 0.5 cc. of 10 N- ethanolic hydrochloric acid and the hydrochloride formed is precipitated by the addition of diethyl ether. There is obtained 1:5 dichloro 9 dimethylamino methyl- 9:10 dihydro 9:10 ethano (1:2) anthracene hydrochloride of the formula c1 se -storag HCJ.

. 170 C. in an autoclave. The residue which remains after melting at 132155 the solution-has been evaporated under reduced pressure isdissolved :in 2 N-sodium hydroxide solution and filtered through carbon. On acidification of the solution crude 1:5 dichloro 9:10 dihydro 9:10 ethano (1:2)- anthracene-Q-carboxylic acid precipitates which is filtered off and dried. 10 grams of this acid are boiled for 2 hours with 200 cc. of thionyl chloride. When the solution has been evaporated there remains an oil Which crystallizes slowly. After recrystallization from petroleum ether there is obtained 1:5 dichloro 9: 10 dihydro- 9: 10 ethano- (1:2)-anthracene-9-carboxylic acid chloride of the formula c1 coo).

EXAMPLE 12 12 of B-[9:l 0-dihydro-9:10-ethano-(1:2)-anthryl]- propionyl chloride in ml. of methylenechloride are stirred dropwise into a solution of 7 g. of fi-hydroxyethylpiperazine in 75 ml. of methylenechloride. The whole is stirred for 3 hours at room temperature, and the precipitate formed is then filtered off. The filtrate is evaporated and the residue dissolved in 2 N-hydrochloric acid and extracted with ether. The acidic extract is alkalinized and extracted with methylenechloride. The methylenechloride is separated, dried over sodium sulfate and evaporated. The residue, (B-[9zlO-dihydro 9:10 ethano-( 1:2)- anthryl1-propionic acid-N'- (,B-hydroxyethyl -pipe1'azide is dissolved in 100 ml. of absolute tetrahydrofuran. This solution is added dropwise to a suspension of 7.5 g. of lithium aluminum hydride in 100 ml. of tetrahydrofuran, and the whole is heated for 2 hours at 50 C., then cooled, whereupon 8 ml. of water, 8 ml. of 15% sodium hydroxide solution and 24 ml. of Water are successively dropped in. The resulting precipitate is filtered 01f and the filtrate is evaporated under vacuum, to leave an oily residue, namely (9-['y-(N'-hydroxyethyl-piperazino)-propyl -9: 10-dihydro9: l-ethano-(1 :2) -anthracene) which is dissolved in 100 ml. of ethanol. On addition of ml. of 10% alcoholic hydrochloric acid a precipitate is obtained which is recrystallized from methanol, to yield 9-['y-(N-hydroxyethyl-piperazino)-propyl] 9:10 dihydro-9: l0-ethano-( l :2 -anthracene dihydrochloride of the formula in white crystals melting at 266 to 268 C.

This product may be incorporated, for example, in tablets of the following composition:

Mg. 9- -(N-hydroxyethyl piperazino) propyl] 9:10- dihydro-9:10-ethano-(1:2) anthracene dihydrochloride 250 Talcum 8 Colloidal silicic acid 2 260 EXAMPLE 13 propionic acid monomethylamide in 150 ml. of absolute tetrahydrofuran are stirred dropwise at room temperature into a suspension of 10 g. of lithium-aluminum hydride in 250 ml. of absolute tetrahydrofuran, and the mixture is heated for 3 hours at 60 C. and then cooled to 10 C. 10 ml. of water and 10 ml. of 15% sodium hydroxide solution are then dropped in and the precipitate formed is filtered oil. The filtrate is evaporated under vacuum, to leave an oil which is dissolved in 50 ml. of ethanol. On addition of 10 N-ethanolic hydrochloric acid and ether, the 9-('y-methylaminopropyl) 9,10-dihydro-9,10- ethano-(1,2)-anthracene hydrochloride of the formula anthryl1-propionic acid monomethylamide which melts at 158 to 161 C. after recrystallization from a mixture of methylenechloride+petroleum ether.

Tablets, each containing 25 mg. of active principle, can be prepared, for example, from the following ingredients:

9 ('y methylamino-propyl) 9,10 dihydro 9,10-

ethano-( 1,2)-anthracene-hydrochloride 25 Lactose Wheat starch 44.4- Colloidal silicic acid 6 Magnesium stearate 0.6 Talc 9 EXAMPLE 14 A solution of 6.8 g. of 13-[10-chloro-9,10dihydro-9*,10- ethano-(1,2)-9-anthryl]-propionic acid dimethylamide in 40 ml. of absolute tetrahydrofuran is stirred dropwise into a suspension of 2.5 g. of lithium-aluminum hydride in ml. of absolute tetrahydrofuran. The mixture is then heated for 3 hours at C., cooled to room temperature and 12 ml. of Water are cautiously added. The precipitate formed is filtered off, and the filtrate evaporated under vacuum, the oily residue dissolved in ether and the ethereal solution is extracted with 2 N-hydrochloric acid. The acid solution is alkalinized with 10 N-sodium hydroxide solution and the precipitated base is extracted with ether. The extract is dried and evaporated, to leave 9-'y-dimethylaminopropyl-10-chloro-9,10-dihydro-9,10 ethano (1-2)- anthracene of the formula whose hydrochloride melts at 225-226 C.

The 3-[10-chlorow9,lO-dihydr0-9,l0-ethano (1,2) 9- anthryl]-prop'ionic acid dimethylamide used as starting material can be prepared in the following manner:

30 grams of 10-chloro-9-anthraldehyde are stirred into a suspension of 8 g. of sodium borohydride in 200 ml. of ethanol. After 1 hour 150 ml. of water are added. A precipitate is formed which is filtered ofi and recrystallized from dimethylformamide+methanol, to yield crystalline 9-hydroxymethyl-10-chloroanthracene melting at 203 205 C.

26 grams of 9-hydroxymethyl-10-chloroanthracene are mixed with 14 g. of thionylchloride in 100 ml. of dioxan and refluxed for 2 hours. After cooling, 9-chloromethyl- IO-chloroanthraeene precipitates in crystalline form. After recrystallization from hexane the compound melts at 168-170 C.

16 grams of malonic acid diethyl ester are added to a suspension of 2.5 g. of sodium hydride in 300 ml. of benzene and the whole is heated for 2 hours at C. 24 grams of 9-chloromethy1-10-chloroanthracene are added and the mixture is refluxed for 7 hours. 200 ml. of water are then added at room temperature and the benzene layer is separated. After evaporation of the solvent 1-(10- chloro-9-anthryl)-2,2-ethanedicarboxylic acid diethyl ester is obtained; after recrystallization from isopropanol it melts at 88-93 C.

When 27 g. of this ester are boiled in a solution of 80 ml. of 2 N-sodium hydroxide solution and ml. of alcohol and then acidified with 5 N-hydrochloric acid, there is obtained the 1-(l0-chloro-9-anthtyl)-ethane-2,2- dicarboxylic acid (melting at 216 C.) which on heating to 220 C. gives rise to /3-(l0-chloro-9-anthryl)-propionic acid by decarboxylation; this compound melts at 194 C. after recrystallization from dioxan+petroleum ether.

A solution of 12 g. of ,8-(10-chlor0-9-anthryl)-propionic acid in 250 g. of toluene is heated in an autoclave with ethylene for 20 hours at 170 C. On cooling, crystalline ,8 [10-chloro-9,10-dihydro-9,10-ethano-( 1,2)-9-anthryl]- propionic acid melting at 280 C. is obtained.

8 grams of this acid are heated for 2 hours with 80 ml. of thionylchloride. On evaporation of the excess thionylchloride, B [10-chloro-9,l0-dihydro-9,10-ethano- (1,2)-9-anthryl]-propionic acid chloride is obtained which melts at 145-150 C. after recrystallization from hexane.

Dim'ethylamine is injected for one hour into a solution of 7.5 got the acid chloride in 75 ml. of benzene. The precipitate formed isfiltered off and the filtrate evaporated under ,vacuum, to leave a residue which is recrystallized from ether, to yield -[10-chloro-9,10-dihydro-9, 10-ethan'o-(1,2)-9-anthryl]-propionic acid dimethylamide in crystals melting at 143-147 C.

EXAMPLE 17 grams of 3-[2-chloro-9,10-dihydro-9,10-ethano(1,2)- 9-anthrylj-propionic acid dimethylamide in 100 ml. of absolute tetrahydrofuran are stirred dropwise into a suspension of 5 g. of lithium-aluminium hydride in 100 ml. of absolute tetrahydrofuran, and the mixture is stirred for 5 hours at 60 C. then cooled and 20 ml. of water are added. The precipitate formed is filtered off and the filtrate evaporated under vacuum, to leave an oil which is mixed with 2 ml. of 10 N-hydrochloric acid in alcohol and ether, to yield '2-chloro-9-' -dimethylaminopropyl-9,IO-dihydro- 9,10-ethano-(1,2)-anthracene hydrochloride of the formula 0H 0H GH N(CH 0890 l which melts at 171-173 C. after recrystallization from isopropanol.

The B [2 chloro-9,10-dihydro-9,10-ethano-(1,2)-9- anthryl]-propionic acid dimethylamide used as starting material is obtained by the methods described in Example 14 from 2-chloroanthracene-(9)-aldehyde via (a) 2-chloro-9-hydroxymethylanthracene (M.P. 140- (b) 2-chloro-9-chloromethylanthracene (M.P. 140-143 (c) 1-(2-chloro-9-anthryl)-2-ethane-dicarboxylic acid diethyl ester (oil).

(d) 1-(2-chloro-9-anthryl)-2-ethane-dicarboxylic acid (M.P. 210 C.)

(e) fi-[2-chloro-9,10-dihydro-9,10-ethano-(1,2)-9-anthryl]-propionic acid (M.P. 170 C.)

(t) B [2 chloro-9,10-dihydro-9,10-ethano-(l,2)-9-anthryl]-propionic acid chloride (oil).

( g) B- [2-chloro-9, 10.-dihydro-9, 10-ethano-( 1,2 )-9-anthryl]-propionic acid dimethylamide (oil).

EXAMPLE 16 A solution of g. of ,3-[3-chloro-9,10-dihydro-9,10- ethano-(1,2)-9-anthryl]-propionic acid dimethylamide in 200 ml. of absolute tetrahydrofuran is stirred dropwise under nitrogen into a suspension of 6 g. of lithium-aluminium hydride in 200 ml. of absolute tetrahydrofuran. The reaction mixture is refluxed for 2 hours, cooled, and 6 ml. of'water, 6 ml. of sodium hydroxide solution of 15% strength and 18 ml. of Water are added. The whole is completely evaporated and the residue dissolved in 200 ml. of 2 N-hydrochloric acid, the solution extracted with ether and the residual aqueous phase is rendered clearly alkaline with concentrated sodium hydroxide solution while being cooled, and extracted with ether. The ethereal ex-. tracts are dried over sodium sulphate and evaporated to form an oily residue which is once more dissolved in ether and mixed with the calculated amount of maleic acid in ether, to yield a crystalline maleate of the formula which melts at 154156 C. after recrystallization from ethanol+ether.

The [3 [3-chloro-9,10-dihydro-9,10-ethano-(1,2)-9-anthryl]-propionic acid dimethylamide used as starting material is obtained in oily form from [3-(3-chloro-9-anthryD- propionic acid (melting at 189190 C.) by reaction with ethylene oxide to form 3-[3-ohloro-9,10-dihydro-9,10- ethano-(l,2)-9-anthryl]-propionic acid (melting at 197- 199 0.), conversion with thionyl chloride into the acid chloride and reaction with dimethylamine.

EXAMPLE 17 A solution of 25 g. of [3-[3-chloro-9,10-dihydro-9,10- ethano (1,2) 9-anthryl]-propionic acid monomethylamide in 200 ml. of absolute tetrahydrofuran is stirred dropwise under nitrogen into a suspension of 6 g. of lithium-aluminium hydride in 200 ml. of absolute tetrahydrofuran. The reaction mixture is refluxed for 2 hours, cooled, and 6 ml. of water, 6 ml. of sodium hydroxide solution of 15% strength and 18 m1. of water are added. The batch is completely evaporated under vacuum, the residue dissolved in 500 ml. of 2 N-hydrochloric acid, the solution extracted with ether and the aqueous residue rendered distinctly alkaline with concentrated sodium hydroxide solution while being cooled, and then extracted with ether. The ethereal extracts are dried over sodium sulphate and evaporated to yield 3-chloro-9-('y-monomethylaminopropyl) 9,10 dihydro 9,10 ethano1,2- anthracene of the formula HCCOOH II HGGOOH .The ,8 [3 chloro-9,10-dihydro-9,10-ethano-(1,2)-9- anthryl]-propionic acid monomethylamide used as starting material is obtained in oily form from methylamine as described in Example 16.

EXAMPLE 18 9,10-dihydro9,10-ethano- (1,2)-anthracene of the formula cranes whose hydrochloride melts at 244-245 C.

EXAMPLE 19 7 grams of N-acetyl-2-chloro-9-ethylaminomethyl-9,10- dihydro-9,10-ethano-(1,2)-anthracene in 50 ml. of absolute tetrahydrofuran are dropped into a suspension of 2 g. of lithium-aluminium hydride in 50 ml. of absolute tetrahydrofuran and the Whole is stirred for 4 hours at 50 C.,' then cooled to room temperature, and 15 ml. of water are cautiously added. The precipitate formed is 15 filtered off and the filtrate evaporated under vacuum-to dryness, to leave an oil which is dissolved in 10 ml. of ethanol.-n addition of 1.5 ml. of 10 N-hydrochloric acid in alcohol and ether, the hydrochloride of 2-chloro- 9 diethylaminoethyl 9,10 dihydro-9,10-ethano-(1,2)-

anthracene of the formula ca 1t(c H settles out in white crystals melting at 231 C.

The N acetyl-2-chloro-9-ethylaminomethyl-9, IO-dihydro-9,l0-ethano(1,2) anthracene used as starting material may be obtained by reacting 2-chloro-9-ethylaminomethyl 9,l0-dihydro-9,l0-ethano(l,2)-anthracene [prepared with ethylamine, as described in Example with acetic anhydride at 110120 C. for 5 hours.

EXAMPLE which melts at 88-91 C. after recrystallization from hexane. The hydrochloride melts above 300 C.

EXAMPLE 21 A solution of 14 g. of N-acetyl-9-ethylaminomethyl- 10 chloro-9,10-dihydro-9,10-ethano-(1,2)-anthracene in ml. of absolute tetrahydrofuran is dropped into 5 g. of lithium-aluminium hydride in 100 ml. of absolute tetrahydrofuran, and the batch is then heated for 4 hours at C., whereupon 20 mlf'of water are cautiously added at room temperature. The precipitate formed is filtered oil and the filtrate evaporated to dryness under vacuum, to yield 9-diethylaminomethyl-10-chloro-9,10- dihydro-9,10ethano-(1,2)-anthracene of the formula CH MC which melts at 116-118" C, after recrystallization "from ethanol. Its hydrochloride melts at ZOO- 205 C.

The. N-acetyl-9-ethylaminomethyl-10-chloro-9,IO-dihydro -9,10-ethano-(1,2)anthracene used: as starting material may be prepared by.reacting.9-ethylaminomethyl- 10-chloro-9,10-dihydro 9,10:ethano- I,2) -anthracene (cf. Example 18) with acetic anhydride at 110 C. The com pound melts at 20 3205 C.

a A EXAMPLE 22 13 grams of 9-dimethylaminomethyl'-v9,lO-dihydro- 9,1'0-ethano-(l,2;)-anthracene are stirred into a mixture of ml; of concentrated sulphuric acid and 10 ml. of concentrated nitric acid, and the mixture is heated for 1 hour at 60- C., then poured over ice and rendered alkaline with -10 N-sodium hydroxide solution. On extraction With methylenechloride, drying and evaporation, a solid residue is obtained which is recrystallized from alcohol, to yield 1,3,6-trinitro-9-dimethylaminomethyl- 9,10-dihydro-9,10-ethano-(1,2 )-anthracene of the formula N02 CH N cH in yellow crystals melting at 183184 C.

We claim: 1. compound of the formula wherein X is a member selected from the group consisting of a lower alkylene radical with at most 3 carbon atoms and a direct bond, R stands for a member selected from the group consisting of hydrogen, halogen and lower alkyl, and R and R each represents a member selected from the group consisting of hydrogen, lower alkyl, lower hydroxy-alkyl, lower monooxaalkyl, lower monoazaalkyl,

. lower. monothiaalkyl, lower alkenyl, cyclo-lower alkyl,

cyclo-lower alkyl-lower alkyl, Ph"-lower-alkyl, and, when taken together, lower alkylene, lower monooxaalkylene, lower monoazaalkylene, lower monothiaalkylene, N-lower aklyl-lower monoazaalkylene and N-(hydroxy-lower alkyl)-lower monoazaalkylene in which monooxaalkylene, monoazaalkylene and monothiaalkylene have 6 to 7 ring members and the hetero atom is separated from the amido nitrogen atom by at least two carbon atoms, and wherein R and R each represents a member selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, halogeno, trifluoromethyl, nitro, and amino, and Ph stands for a member selected from the group consisting of phenyl, lower alkoxy-phenyl, lower alkyl-phenyl, halogeno-phenyl, trifiuoromethyl-phenyl, and amino-phenyl, and the lower alkyl and alkenyl portion in said substituents have at most 7 carbon atoms and the cycle-alkyl portionsin said substituents have from 4 to 7 ring carbon atoms.

2. A compound as claimed in claim 1, wherein X is a direct bond, R is lower alkyl and R hydrogen or lower alkyl and R and R are hydrogen.

3. A compound as claimed in claim 1, wherein X is ethylene-(1:2), R is lower alkyl and R hydrogen or lower alkyl and R and R are hydrogen.

4. A compound as claimed in claim 1, wherein X is a I direct bond, R is lower alkyl and R hydrogen or lower allcyl and R and R are hydrogen or halogen, at least one of them being halogen.

5. *A compound as claimed in claim 1, wherein X is ethylene-(1:2), R is lower alkyl and R hydrogen or lower alkyl and R and R are hydrogen or halogen, at least one of them being halogen. I

6. (B-[9z10-dihydro-9:10-ethano-(lz2) anthryl]-pro pionic acid-N-(,B-hydroxyethyl) -pip'erazide) 7. fi-[9zl0-dihydro-9:10-ethano-(1 :2)-9 anthryl]-propionic acid monomethylamide.

17 18 8. fi-[l0-chlore-9z10 dihydr0-9: 10 ethano-(1:2)-9 References Cited anthryl] 'Pmplomc acld dlmethylamlde' Marrazzi, Ann. NY. Acad. Science, vol. 96, pp. 211-26 9. fl-[Z-chloro 9:10-dihydro-9z10-ethan0 (1:2)-9- (1962). anthryH-propionic acid dimethylamide.

10. 9:10-dihydro-9:10-ethano-(122) anthracene-(9) 5 ALEX MAZEL Primary Examiner carboxylic acid methylamide.

11. A compound as claimed in claim 1, said compound DAUS Asslstant Exammer being a member of the group consisting of the 9:10-di- U S Cl XR hydro-9:10-ethan0-(1:2)-anthracene-(9)-carb0xy1ic acid diethylamide and the B-propionic acid dimethylamide. 10 99-2; 260-558, 690, 999

CASE M687/ l+2/ 53 5 7/3/ CIP 1.

*zgz g i UNITED STATES PATENT OFFICE CERTIFICATE OF CORRECTION Patent No. 5519 d July 15, 1969 Inventor(s) PAUL SCHMIDT ET AL and that said Letters Patent are hereby corrected as It is certified that error appears in the above-identified patent shown below:

Col. 1, line 5%, after "traninsert quilizers The new intermediates are converted into the Col 3, line 20, after "more", delete "more".

Col 5, line 49, "(1: 2anthra,cene" should read (l: 2)

anthracene- Col. 6, line 3 "ethano-(l: should read ethane-(1: 2)

C01 12, line 31, "(1-2) should read (1,2)

Col. 17, line 10, after "the 6-", insert [9: lO-dihydro- 9:10-ethano-(l: 2)9-anthryl] ton-:0 AND SEIlI- 3AA 1971 Meal:

ldwudllFlachar It.

will I m Atwfi g 0mm! Commissioner 0:8 Patents 

